Lactobacillus plantarum strains attenuated DSS-induced colitis in mice by modulating the gut microbiota and immune response / Las cepas de Lactobacillus plantarum atenuaron la colitis inducida por DSS en ratones mediante la modulación de la microbiota intestinal y la respuesta inmunitaria
Int. microbiol
; 25(3): 587-603, Ago. 2022. ilus, tab
Article
em En
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| ID: ibc-216217
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Localização: ES15.1 - BNCS
ABSTRACT
Gut microbiota has become a new therapeutic target in the treatment of inflammatory Bowel Disease (IBD). Probiotics are known for their beneficial effects and have shown good efficacy in the clinical treatment of IBD and animal models of colitis. However, how these probiotics contribute to the amelioration of IBD is largely unknown. In the current study, the DSS-induced mouse colitis model was treated with oral administration of Lactobacillus plantarum strains to investigate their effects on colitis. The results indicated that the L. plantarum strains improved dysbiosis and enhanced the abundance of beneficial bacteria related to short-chain fatty acids (SCFAs) production. Moreover, L. plantarum strains decreased the level of pro-inflammatory cytokines, i.e., IL-17A, IL-17F, IL-6, IL-22, and TNF-α and increased the level of anti-inflammatory cytokines, i.e., TGF-β, IL-10. Our result suggests that L. plantarum strains possess probiotic effects and can ameliorate DSS colitis in mice by modulating the resident gut microbiota and immune response.(AU)
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Coleções:
06-national
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ES
Base de dados:
IBECS
Assunto principal:
Doenças Inflamatórias Intestinais
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Probióticos
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Lactobacillus plantarum
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Disbiose
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Microbioma Gastrointestinal
Limite:
Animals
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Humans
Idioma:
En
Revista:
Int. microbiol
Ano de publicação:
2022
Tipo de documento:
Article