Rechazo humoral en transplante cardíaco: comunicación de dos casos / Humoral rejection in heart transplantation: report of 2 cases
Rev. méd. Chile
; 128(11): 1245-49, nov. 2000.
Article
em Es
| LILACS
| ID: lil-282151
Biblioteca responsável:
CL1.1
ABSTRACT
Heart transplantation is a therapeutic alternative for selected patients with refractory heart failure. Acute allograft rejection is one of the main causes of early death after transplantation. The cellular rejection is characterized by cellular infiltrates with or without miocyte necrosis. However, some patients develop left ventricular dysfunction due to rejection without evidence of cellular infiltration. In these patients, the rejection is mediated by antibodies and complement. Humoral rejection is a relative rare but potentially fatal form of acute allograft rejection. We report two patients with left ventricular dysfunction secondary to humoral rejection, shortly after cardiac transplantation. Both patients were treated with methylprednisolone, and azathioprine was substituted by cyclophosphamide. One patient underwent plasmapheresis. The clinical outcome was satisfactory and the left ventricular function returned to normal in both cases. The diagnostic and therapeutic strategies for the management of humoral rejection are reviewed
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Transplante de Coração
/
Oclusão de Enxerto Vascular
/
Rejeição de Enxerto
Limite:
Humans
/
Male
Idioma:
Es
Revista:
Rev. méd. Chile
Assunto da revista:
MEDICINA
Ano de publicação:
2000
Tipo de documento:
Article