Non-selective cation channels and oxidative stress-induced cell swelling
Biol. Res
; 35(2): 215-222, 2002. graf
Article
em En
| LILACS
| ID: lil-323344
Biblioteca responsável:
BR1.1
RESUMO
Necrosis is considered as a non-specific form of cell death that induces tissue inflammation and is preceded by cell swelling. This increase in cell volume has been ascribed mainly to defective outward pumping of Na+ caused by metabolic depletion and/or to increased Na+ influx via membrane transporters. A specific mechanism of swelling and necrosis driven by the influx of Na+ through nonselective cation channels has been recently proposed (Barros et al., 2001a). We have characterized further the properties of the nonselective cation channel (NSCC) in HTC cells. The NSCC shows a conductance of approximately 18 pS, is equally permeable to Na+ and K+, impermeant to Ca2+, requires high intracellular Ca2+ as well as low intracellular ATP for activation and is inhibited by flufenamic acid. Hydrogen peroxide induced a significant increase in cell volume that was dependent on external Na+. We propose that the NSCC, which is ubiquitous though largely inactive in healthy cells, becomes activated under severe oxidative stress. The ensuing Na+ influx initiates via positive feedback a series of metabolic and electrolytic disturbances, resulting in cell death by necrosis
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Carcinoma Hepatocelular
/
Estresse Oxidativo
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Canais Iônicos
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Neoplasias Hepáticas
Limite:
Animals
Idioma:
En
Revista:
Biol. Res
Assunto da revista:
BIOLOGIA
Ano de publicação:
2002
Tipo de documento:
Article
/
Project document
País de afiliação:
Chile