Nueva variante en el polimorfismo del intrón 4 de la enzima Oxido Nítrico Sintasa endotelial (eNOS) / A new variant of the polymorphism in the fourth intron from the endothelial nitric oxide synthase enzyme

ABSTRACT

Nitric oxide (NO) derived from endothelial Nitric Oxide Synthase enzyme (eNOS) is an important mediator of the vascular function. Various polymorphisms have been described for the eNOS gene that has effects on its expression. One of the most studied markers in the eNOS gen is located in the fourth intron and is characterized by the presence of a variable number of tandemly repeated sequence of 27 base pairs. In this work we report the existence and the sequence of a new variant for these polymorphism and we hypothestize its potential role in the regulation of NO productition by eNOS.