The pharmacokinetics and pharmaco-dynamics of Procysteine in amyotrophic lateral sclerosis.
Neurology
; 52(7): 1492-4, 1999 Apr 22.
Article
em En
| MEDLINE
| ID: mdl-10227642
ABSTRACT
In 13 subjects with ALS, we studied the safety and pharmacokinetic properties of Procysteine, a cysteine prodrug that increases levels of intracellular glutathione. We found that oral administration of Procysteine was safe. Procysteine enters CSF after both IV and oral dosing and accumulates to significant levels in CSF. We also observed that CSF levels of glutathione fall dramatically with aging.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tiazóis
/
Esclerose Lateral Amiotrófica
Limite:
Adult
/
Humans
/
Middle aged
Idioma:
En
Revista:
Neurology
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Estados Unidos