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Calbindin immunoreactivity in the hippocampal formation and neocortex of schizophrenics.
Iritani, S; Kuroki, N; Ikeda, K; Kazamatsuri, H.
Afiliação
  • Iritani S; Dept. of Psychiatry, Tokyo Metropolitan Matsuzawa Hospital, Japan. shuiritani@aol.com
Article em En | MEDLINE | ID: mdl-10378226
1. The authors studied the morphology of CalbindinD28K (CaBp) immunoreactive cells and processes in the hippocampal formation and the prefrontal cortex of schizophrenics using the immunohistochemical technique of avidin-biotin-complex method (ABC method), and the results were compared with those from normal human brains. 2. In the hippocampal formation area CA2 of schizophrenics, many CaBp-immunopositive cell bodies and fibers were disordered in their arrangement compared to normal control brains. 3. In the prefrontal cortex (Brodmann area 9) of schizophrenics, many immunopositive cell bodies were exhibited irregular axis arrangement and fiber disarray. 4. The altered distribution pattern of CaBp-immunopositive structures in the hippocampal formation and the prefrontal cortex might indicate the existence of GABA(gamma-aminobutyric acid)ergic dysfunction in the brain of schizophrenic patients.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Proteína G de Ligação ao Cálcio S100 / Neocórtex / Hipocampo Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Japão
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Esquizofrenia / Proteína G de Ligação ao Cálcio S100 / Neocórtex / Hipocampo Limite: Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Prog Neuropsychopharmacol Biol Psychiatry Ano de publicação: 1999 Tipo de documento: Article País de afiliação: Japão