A non-toxic analogue of a coeliac-activating gliadin peptide: a basis for immunomodulation?
Aliment Pharmacol Ther
; 13(7): 945-50, 1999 Jul.
Article
em En
| MEDLINE
| ID: mdl-10383530
ABSTRACT
BACKGROUND:
A-gliadin residues 31-49 (peptide A) binds to HLA-DQ2 and is toxic to coeliac small bowel. Analogues of this peptide, which bind to DQ2 molecules but are non-toxic, may be a potential route to inducing tolerance to gliadin in patients with coeliac disease.METHODS:
Toxicity was investigated with small bowel organ culture in six patients with untreated coeliac disease, four with treated coeliac disease and six controls. Analogue peptides comprised alanine substituted variants of peptide A at L31 (peptide D), P36 (E), P38 (F), P39 (G) and P42 (H).RESULTS:
Peptides D and E were toxic in biopsies from some patients. Peptides F, G and H were not toxic.CONCLUSIONS:
Peptide F, which binds to DQ2 more strongly than peptide A, is not toxic in patients with coeliac disease in-vitro; this could be an initial step towards investigation of the induction of tolerance to gliadin in patients affected by coeliac disease.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Fragmentos de Peptídeos
/
Antígenos HLA-DQ
/
Doença Celíaca
/
Gliadina
Tipo de estudo:
Observational_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Aliment Pharmacol Ther
Assunto da revista:
FARMACOLOGIA
/
GASTROENTEROLOGIA
/
TERAPIA POR MEDICAMENTOS
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Reino Unido