[Transcutaneous radiotherapy after thyroidectomy for differentiated thyroid carcinoma]. / La radioterapia transcutanea dopo tiroidectomia per carcinoma tiroideo differenziato.
Clin Ter
; 150(2): 103-7, 1999.
Article
em It
| MEDLINE
| ID: mdl-10396858
ABSTRACT
PURPOSE:
To compare the results, in terms of 10-year actuarial survival, between I-131-therapy and I-131-therapy + external beam radiotherapy (RT) in patients operated on for differentiated thyroid carcinoma. PATIENTS ANDMETHODS:
Over a period of 13 years (1982-1995) 408 patients underwent thyroidectomy with or without linphoadenectomy for pT0/T4 Nx or pN0, pN1a, pN1b thyroid carcinoma. In all cases, thyroidectomy was radical. Patients were divided into two groups, which were comparable according to several prognostic factors group A composed of 165 patients (surgery + I-131) and group B, 243 patients (surgery + I-131 + RT).RESULTS:
The percentage of deaths related to relapsed or metastatic thyroid carcinoma was 6.25%. In the group treated with adjuvant radiotherapy, 14.8% of the patients experienced acute tracheal or esophageal side effects. Late toxicity (mouth dryness, skin and/or muscle fibrosis) was recorded only in a small percentage of the patients (2.4%).CONCLUSIONS:
Adjuvant RT resulted in a statistically significant improvement (p < 0.01) in survival of patients with extracapsular diffusion of the cancer, especially those with pT4 N1b tumors or tumors involving the trachea.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Glândula Tireoide
/
Carcinoma
Tipo de estudo:
Clinical_trials
/
Prognostic_studies
Limite:
Humans
Idioma:
It
Revista:
Clin Ter
Ano de publicação:
1999
Tipo de documento:
Article
País de afiliação:
Itália