Monoclonal Epstein-Barr virus-related lymphoproliferative disorder following adult acute lymphoblastic leukaemia.
Br J Haematol
; 106(3): 713-6, 1999 Sep.
Article
em En
| MEDLINE
| ID: mdl-10468862
ABSTRACT
A 31-year-old patient in remission of acute lymphoblastic leukaemia (ALL), receiving oral maintenance chemotherapy (6-mercaptopurine, methotrexate (MTX), cyclophosphamide), developed a monoclonal, Epstein-Barr virus (EBV)-related lymphoproliferative disorder (LPD). Treatment consisted of excisional biopsy and the discontinuation of maintenance chemotherapy. To our knowledge, this is the first such report in an adult. The histological similarity to previous reports of 'lymphomatoid granulomatosis' following paediatric ALL suggests that they are the same disease. MTX may play a central role in the development of LPD in this setting. Although it is a rare complication of ALL, EBV-related LPD should be considered in patients who develop lymphadenopathy.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções Tumorais por Vírus
/
Herpesvirus Humano 4
/
Infecções por Herpesviridae
/
Leucemia-Linfoma Linfoblástico de Células Precursoras
/
Transtornos Linfoproliferativos
Limite:
Adult
/
Humans
/
Male
Idioma:
En
Revista:
Br J Haematol
Ano de publicação:
1999
Tipo de documento:
Article