Digitalis pharmacokinetics and metabolism.
Am J Med
; 58(4): 452-9, 1975 Apr.
Article
em En
| MEDLINE
| ID: mdl-1092160
ABSTRACT
The pharmacokinetics of the cardiac glycofides have been elucidated as a result of the development of assays of sufficient sensitivity to measure the concentration of digitalis compounds in biological fluids. Digoxin can accumulate in the body without the administration of a loading dose, and a steady state blood concentration will be reached in 5 to 7 days. Digitoxin requires 35 days to accumulate to a plateau. If a loading dose of digoxin is used, it should be approximately three times the estimated daily maintenance dose. Factors that determine the selection of the appropriate maintenance dose of digoxin include renal function and lean body mass. Digitoxin is less dependent on renal function for its elimination than is digoxin. Knowledge of the pharmacokinetics of digitalis preparations is useful in determining how to change from one cardiac glycoside to another, each with different half-lives. One should wait 3 days before starting digoxin therapy when changing from maintenance digitoxin to digoxin (assuming normal renal function). The pharmacokinetics of changing from ouabain to digoxin without loss of digitalis effect are described. The metabolism of the commonly used digitalis preparations are summarized.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Glicosídeos Digitálicos
Limite:
Humans
Idioma:
En
Revista:
Am J Med
Ano de publicação:
1975
Tipo de documento:
Article