Tetracationic porphyrins inhibit angiogenesis induced by human tumor cells in vivo.
Anticancer Res
; 20(5A): 3205-10, 2000.
Article
em En
| MEDLINE
| ID: mdl-11062744
ABSTRACT
BACKGROUND:
Cationic porphyrin TMPyP4, but not its isomer TMPyP2, inhibits telomerase in tumor cells in vitro and induces chromosome destabilization in vivo. MATERIALS ANDMETHODS:
To examine the effects of these porphyrins on tumor-induced angiogenesis, 25-200 micrograms TMPyP4 or TMPyP2 were injected daily for 3 days in mice with intradermally implanted primary human tumor cells. Alternatively, tumor cells were exposed for 90 minutes to 2.5-20 microM porphyrins prior to implantation in mice.RESULTS:
Either subcutaneous injections (> or = 50 micrograms/mouse) or preincubation with > or = 5 microM porphyrins significantly inhibited angiogenesis.CONCLUSION:
Antiangiogenic activity is apparently unrelated to the ability of the porphyrins to inhibit telomerase.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Porfirinas
/
Inibidores da Angiogênese
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Anticancer Res
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos