Trisomy 1q, 2, and 20 in a case of hepatoblastoma: possible significance of 2q35-q37 and 1q12-q21 rearrangements.
Cancer Genet Cytogenet
; 123(2): 140-3, 2000 Dec.
Article
em En
| MEDLINE
| ID: mdl-11150606
ABSTRACT
Combined cytogenetic, chromosome painting, and spectral karyotyping (SKY) analyses in a case of hepatoblastoma revealed a karyotype of 49,XY,+Y,+der(2)t(2;3)(q35;q25),der(3)t(1;3)(q12; q25),+20. Trisomy 1q, 2, and 20 identified in the present case are consistent with the previously reported cytogenetic alterations in hepatoblastoma. The breakpoints at 1q12 and 2q35 identified in this case have also been reported previously as nonrandom changes. The frequent occurrence of these rearrangements in hepatoblastoma suggests that they may be of pathogenic significance.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Trissomia
/
Cromossomos Humanos Par 1
/
Cromossomos Humanos Par 2
/
Cromossomos Humanos Par 20
/
Hepatoblastoma
/
Neoplasias Hepáticas
Tipo de estudo:
Prognostic_studies
Limite:
Humans
/
Infant
/
Male
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
2000
Tipo de documento:
Article
País de afiliação:
Estados Unidos