[One-pot synthesis of dl-naproxen by rearrangement].

Hu, A X; Dong, X M; Cao, S C; Cheng, Y P; Chen, L

Hu, A X; Dong, X M; Cao, S C; Cheng, Y P; Chen, L.

Afiliação

Hu AX; College of Chemistry and Chemical Engineering, Hunan University, Changsha 410082, China. huaixi@mail.hunu.edu.cn

Yao Xue Xue Bao ; 35(11): 818-20, 2000 Nov.

Article em Zh | MEDLINE | ID: mdl-11218856

RESUMO

AIM: To synthesize dl-naproxen by rearrangement method. METHODS: dl-Naproxen was synthesized by halogenation, ketalization, rearrangement and hydrolysis, using cupric halide as halogenation agent. RESULTS: Total yields were 74.0%-92.6% based on 6-methoxy-2-propionyl naphthalene. CONCLUSION: Total yield was higher by one-pot rearrangement approach.

Assuntos

Anti-Inflamatórios não Esteroides/síntese química; Naproxeno/síntese química; Compostos Organometálicos/metabolismo; Hidrólise

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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Compostos Organometálicos / Anti-Inflamatórios não Esteroides / Naproxeno Idioma: Zh Revista: Yao Xue Xue Bao Ano de publicação: 2000 Tipo de documento: Article País de afiliação: China

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