The physical maps for sequencing human chromosomes 1, 6, 9, 10, 13, 20 and X.
Nature
; 409(6822): 942-3, 2001 Feb 15.
Article
em En
| MEDLINE
| ID: mdl-11237015
ABSTRACT
We constructed maps for eight chromosomes (1, 6, 9, 10, 13, 20, X and (previously) 22), representing one-third of the genome, by building landmark maps, isolating bacterial clones and assembling contigs. By this approach, we could establish the long-range organization of the maps early in the project, and all contig extension, gap closure and problem-solving was simplified by containment within local regions. The maps currently represent more than 94% of the euchromatic (gene-containing) regions of these chromosomes in 176 contigs, and contain 96% of the chromosome-specific markers in the human gene map. By measuring the remaining gaps, we can assess chromosome length and coverage in sequenced clones.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomo X
/
Cromossomos Humanos Par 1
/
Cromossomos Humanos Par 6
/
Cromossomos Humanos Par 10
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Cromossomos Humanos Par 13
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Cromossomos Humanos Par 20
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Genoma Humano
/
Mapeamento de Sequências Contíguas
Limite:
Humans
Idioma:
En
Revista:
Nature
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Reino Unido