Plant-based vaccines: unique advantages.
Vaccine
; 19(17-19): 2742-8, 2001 Mar 21.
Article
em En
| MEDLINE
| ID: mdl-11257418
ABSTRACT
Numerous studies have shown that viral epitopes and subunits of bacterial toxins can be expressed and correctly processed in transgenic plants. The recombinant proteins induce immune responses and have several benefits over current vaccine technologies, including increased safety, economy, stability, versatility and efficacy. Antigens expressed in corn are particularly advantageous since the seed can be produced in vast quantities and shipped over long distances at ambient temperature, potentially allowing global vaccination. We have expressed the B-subunit of Escherichia coli heat-labile enterotoxin and the spike protein of swine transmissible gastroenteritis virus at high levels in corn, and demonstrate that these antigens delivered in the seed elicit protective immune responses.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Vacinas Sintéticas
/
Plantas Geneticamente Modificadas
/
Proteínas de Escherichia coli
Limite:
Animals
Idioma:
En
Revista:
Vaccine
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Estados Unidos