Ontogenesis of protein kinase C betaII and its anchoring protein RACK1 in the maturation of alveolar macrophage functional responses.
Immunol Lett
; 76(2): 89-93, 2001 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-11274725
ABSTRACT
Alveolar macrophages are the resident airway cells primarily responsible for the protection of the lungs against inhaled toxins and other biologically active materials. The purpose of this study was to investigate the maturation with age of alveolar macrophage functional responses. We characterised the ontogenesis of PKC betaII and its anchoring protein RACK1 in correlation with PKC-dependent immune functions, such as TNF-alpha, hydrogen peroxide production and lysozyme release in resident alveolar macrophages obtained from rats 2, 4 and 12 weeks old. Our results show an age-associated increase in the expression of PKC betaII and RACK1, which correlated with a maturation of alveolar macrophage functional responses.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Peptídeos
/
Proteína Quinase C
/
Envelhecimento
/
Macrófagos Alveolares
/
Isoenzimas
Limite:
Animals
Idioma:
En
Revista:
Immunol Lett
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Itália