Treatment of alpha1-antitrypsin-deficiency panniculitis with minocycline.
Cutis
; 68(2): 86-8, 2001 Aug.
Article
em En
| MEDLINE
| ID: mdl-11534920
A small proportion of patients with alpha1-antitrypsin (alpha1AT) deficiency experience recurrent ulcerating panniculitis. Studies suggest that alpha1AT-deficiency panniculitis reflects an uncontrolled inflammatory process because of the serum's incapacity to neutralize proteolytic enzymes released by leukocytes in the skin. Dapsone is considered the treatment of choice for this entity, but it is limited by its side effects, especially hematologic ones. Tetracyclines have anticollagenase and anti-inflammatory activity and have been used successfully to treat this type of panniculitis. We report the case of a 42-year-old woman with recurrent alpha1AT-deficiency panniculitis who did not tolerate the side effects of dapsone or systemic corticosteroid. Minocycline treatment led to disappearance of lesions, and long-term administration prevented recurrences without evident negative side effects. We consider minocycline a safe treatment that allows control of alpha1AT-deficiency panniculitis.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Paniculite
/
Deficiência de alfa 1-Antitripsina
/
Minociclina
/
Antibacterianos
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cutis
Ano de publicação:
2001
Tipo de documento:
Article
País de afiliação:
Espanha