Long term health and neurodevelopment in children exposed to antiepileptic drugs before birth.
J Med Genet
; 39(4): 251-9, 2002 Apr.
Article
em En
| MEDLINE
| ID: mdl-11950853
ABSTRACT
OBJECTIVE:
To investigate the frequency of neonatal and later childhood morbidity in children exposed to antiepileptic drugs in utero.DESIGN:
Retrospective population based study.SETTING:
Population of the Grampian region of Scotland.PARTICIPANTS:
Mothers taking antiepileptic drugs in pregnancy between 1976 and 2000 were ascertained from hospital obstetric records and 149 (58% of those eligible) took part. They had 293 children whose health and neurodevelopment were assessed. MAIN OUTCOMEMEASURES:
Frequencies of neonatal withdrawal, congenital malformations, childhood onset medical problems, developmental delay, and behaviour disorders.RESULTS:
Neonatal withdrawal was seen in 20% of those exposed to antiepileptic drugs. Congenital malformations occurred in 14% of exposed pregnancies, compared with 5% of non-exposed sibs, and developmental delay in 24% of exposed children, compared with 11% of non-exposed sibs. After excluding cases with a family history of developmental delay, 19% of exposed children and 3% of non-exposed sibs had developmental delay, 31% of exposed children had either major malformations or developmental delay, 52% of exposed children had facial dysmorphism compared with 25% of those not exposed, 31% of exposed children had childhood medical problems (13% of non-exposed sibs), and 20% had behaviour disorders (5% of non-exposed).CONCLUSION:
Prenatal antiepileptic drug exposure in the setting of maternal epilepsy is associated with developmental delay and later childhood morbidity in addition to congenital malformation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Exposição Materna
/
Epilepsia
/
Doenças Fetais
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Anticonvulsivantes
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
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Adult
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Child
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Child, preschool
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Female
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Humans
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Infant
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Newborn
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Pregnancy
Idioma:
En
Revista:
J Med Genet
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Reino Unido