In vitro remifentanil metabolism: the effects of whole blood constituents and plasma butyrylcholinesterase.
Anesth Analg
; 95(5): 1305-7, table of contents, 2002 Nov.
Article
em En
| MEDLINE
| ID: mdl-12401616
ABSTRACT
UNLABELLED We designed this in vitro study to determine whether the half-life of remifentanil was altered in butyrylcholinesterase-deficient patients. Test tubes containing Krebs buffered solution, whole blood, plasma, or red cells from both normal and butyrylcholinesterase-deficient patients were incubated with remifentanil. Remifentanil concentrations were determined by using gas chromatography and mean half-lives were calculated by using a nonlinear regression analysis. There were no differences in whole blood, red cells, or plasma half-life between normal and butyrylcholinesterase-deficient volunteers. In both normal and butyrylcholinesterase-deficient volunteers, whole blood and plasma had a significantly longer half-life than the red cell component. Extrapolation to the in vivo setting would suggest that a butyrylcholinesterase-deficient patient should not have altered remifentanil kinetics. IMPLICATIONS This was a test-tube-designed study to determine whether an enzyme deficiency (butyrylcholinesterase deficiency) changes the way remifentanil is metabolized. It seems that remifentanil dosage does not need to be changed in patients with butyrylcholinesterase deficiency.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperidinas
/
Butirilcolinesterase
/
Anestésicos Intravenosos
Limite:
Adult
/
Humans
Idioma:
En
Revista:
Anesth Analg
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos