Mitogen-activated protein kinase pathways mediated by ERK, JNK, and p38 protein kinases.
Science
; 298(5600): 1911-2, 2002 Dec 06.
Article
em En
| MEDLINE
| ID: mdl-12471242
ABSTRACT
Multicellular organisms have three well-characterized subfamilies of mitogen-activated protein kinases (MAPKs) that control a vast array of physiological processes. These enzymes are regulated by a characteristic phosphorelay system in which a series of three protein kinases phosphorylate and activate one another. The extracellular signal-regulated kinases (ERKs) function in the control of cell division, and inhibitors of these enzymes are being explored as anticancer agents. The c-Jun amino-terminal kinases (JNKs) are critical regulators of transcription, and JNK inhibitors may be effective in control of rheumatoid arthritis. The p38 MAPKs are activated by inflammatory cytokines and environmental stresses and may contribute to diseases like asthma and autoimmunity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Proteínas Quinases Ativadas por Mitógeno
/
Sistema de Sinalização das MAP Quinases
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Science
Ano de publicação:
2002
Tipo de documento:
Article
País de afiliação:
Estados Unidos