Changes in hippocampal acetylcholine and glutamate extracellular levels during soman-induced seizures: influence of septal cholinoceptive cells.
Neurosci Lett
; 139(1): 104-7, 1992 May 11.
Article
em En
| MEDLINE
| ID: mdl-1357600
ABSTRACT
The changes in extracellular acetylcholine and glutamate levels were determined, during the course of seizures induced by soman, an irreversible inhibitor of acetylcholinesterase, in the CA1 hippocampal area of rats previously injected with atropine or normal saline into septum. The marked increases observed in soman-treated animals were abolished in rats receiving atropine. These data strongly suggest that, during soman intoxication, septal cholinoceptive cells play a key role in controlling the release of acetylcholine and glutamate in hippocampus. The mechanisms underlying this phenomenon are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Soman
/
Acetilcolina
/
Receptores Colinérgicos
/
Glutamatos
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
França