Abnormal coronary function in mice deficient in alpha1H T-type Ca2+ channels.
Science
; 302(5649): 1416-8, 2003 Nov 21.
Article
em En
| MEDLINE
| ID: mdl-14631046
ABSTRACT
Calcium ion (Ca2+) influx through voltage-gated Ca2+ channels is important for the regulation of vascular tone. Activation of L-type Ca2+ channels initiates muscle contraction; however, the role of T-type Ca2+ channels (T-channels) is not clear. We show that mice deficient in the alpha1H T-type Ca2+ channel (alpha(1)3.2-null) have constitutively constricted coronary arterioles and focal myocardial fibrosis. Coronary arteries isolated from alpha(1)3.2-null arteries showed normal contractile responses, but reduced relaxation in response to acetylcholine and nitroprusside. Furthermore, acute blockade of T-channels with Ni2+ prevented relaxation of wild-type coronary arteries. Thus, Ca2+ influx through alpha1H T-type Ca2+ channels is essential for normal relaxation of coronary arteries.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Artérias
/
Vasodilatação
/
Cálcio
/
Vasos Coronários
/
Canais de Cálcio Tipo T
Limite:
Animals
Idioma:
En
Revista:
Science
Ano de publicação:
2003
Tipo de documento:
Article
País de afiliação:
Estados Unidos