Tissue engineering for cartilage repair: in vitro properties of a hyaluronan-derivative.
Chir Organi Mov
; 88(4): 351-5, 2003.
Article
em En, It
| MEDLINE
| ID: mdl-15259550
ABSTRACT
Association of biomaterials with autologous cells can provide a new generation of implantable devices for cartilage and bone repair. Such scaffolds should provide a performed three-dimensional shape, prevent cells from floating out of the defect, have sufficient mechanical strength, facilitate uniform spread of cells, and stimulate the phenotype of transplanted cells. Hyaff-11 is a recently developed hyaluronic-acid based biodegradable polymer, that has been shown to provide successful cell scaffolds for tissue-engineered repair. The aim of this study was to evaluate in vitro the potential of Hyaff-11 to support the growth of human chondrocytes and to maintain their original phenotype. Our data indicate that human chondrocytes seeded on Hyaff-11 express and produce collagen type II and aggrecan and downregulate the production of collagen type I. These results provide an in vitro demonstration of therapeutic potential of Hyaff-11 as a delivery vehicle in tissue-engineered repair of articular cartilage defects.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cartilagem
/
Engenharia Tecidual
/
Ácido Hialurônico
Limite:
Adolescent
/
Adult
/
Humans
Idioma:
En
/
It
Revista:
Chir Organi Mov
Ano de publicação:
2003
Tipo de documento:
Article