Clustering of Parkinson disease: shared cause or coincidence?
Arch Neurol
; 61(7): 1057-60, 2004 Jul.
Article
em En
| MEDLINE
| ID: mdl-15262735
ABSTRACT
BACKGROUND:
The spatial and temporal pattern of excessive disease occurrence, termed clustering, may provide clues about the underlying etiology.OBJECTIVE:
To report the occurrence of 3 clusters of Parkinson disease (PD) in Canada. DESIGN AND PATIENTS We determined the population groups containing the clusters, geographical limits, and duration of exposure to the specific environments. We tested whether there was an excessive presence of Parkinson disease by calculating the probability of the observed cases occurring under the null hypothesis that the disease developed independently and at random in cluster subjects. Results of genetic testing for mutations in the alpha-synuclein, parkin, tau genes, and spinocerebellar ataxia genes (SCA2 and SCA3) were negative.RESULTS:
The probabilities of random occurrence (P values) in the 3 clusters were P = 7.9 x 10 (-7)for cluster 1, P = 2.6 x 10 (-7)for cluster 2, and P = 1.5 x 10 (-7)for cluster 3.CONCLUSIONS:
Our findings indicate an important role for environmental causation in Parkinson disease. A possible role exists for environmental factors such as viral infection and toxins in the light of current evidence.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doença de Parkinson
/
Meio Ambiente
Tipo de estudo:
Etiology_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Arch Neurol
Ano de publicação:
2004
Tipo de documento:
Article