Using support vector classification for SAR of fentanyl derivatives.
Acta Pharmacol Sin
; 26(1): 107-12, 2005 Jan.
Article
em En
| MEDLINE
| ID: mdl-15659122
ABSTRACT
AIM:
To discriminate between fentanyl derivatives with high and low activities.METHODS:
The support vector classification (SVC) method, a novel approach, was employed to investigate structure-activity relationship (SAR) of fentanyl derivatives based on the molecular descriptors, which were quantum parameters including DeltaE [energy difference between highest occupied molecular orbital energy (HOMO) and lowest empty molecular orbital energy (LUMO)], MR (molecular refractivity) and M(r) (molecular weight).RESULTS:
By using leave-one-out cross-validation test, the accuracies of prediction for activities of fentanyl derivatives in SVC, principal component analysis (PCA), artificial neural network (ANN) and K-nearest neighbor (KNN) models were 93%, 86%, 57%, and 71%, respectively. The results indicated that the performance of the SVC model was better than those of PCA, ANN, and KNN models for this data.CONCLUSION:
SVC can be used to investigate SAR of fentanyl derivatives and could be a promising tool in the field of SAR research.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Algoritmos
/
Análise Numérica Assistida por Computador
/
Fentanila
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
Acta Pharmacol Sin
Assunto da revista:
FARMACOLOGIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China