Docking: successes and challenges.
Curr Pharm Des
; 11(3): 323-33, 2005.
Article
em En
| MEDLINE
| ID: mdl-15723628
ABSTRACT
The state of the art of various computational aspects of docking-based virtual screening of database of small molecules is presented. The review encompasses the different search algorithms and the scoring functions used in docking methods and their applications to protein and nucleic acid drug targets. Recent progress made in the development and application of methods to include target flexibility are summarized. The fundamental issues and challenges involved in comparing various docking methods are discussed. Limitations of current technologies as well as future prospects are presented.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Tecnologia Farmacêutica
/
Proteínas de Membrana
Idioma:
En
Revista:
Curr Pharm Des
Assunto da revista:
FARMACIA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos