[The expression of galanin and galanin receptors in olfactory ensheathing cells and effects of galanin on cells proliferation].
Shi Yan Sheng Wu Xue Bao
; 38(2): 98-104, 2005 Apr.
Article
em Zh
| MEDLINE
| ID: mdl-16011241
ABSTRACT
Olfactory ensheathing cells (OECs) were isolated from newborn rat olfactory bulb and cultured in vitro. RT-PCR was used to determine the expression of galanin and it's receptors in these cells. MTT analysis was used to detect the effects of galanin and agonist, antagonist of galanin receptors on the proliferation of OECs. Results show that OECs express mRNAs for galanin and GalR2 but not for two another receptors, GalR1 and GalR3. In addition, galanin and two receptor agonists, GAL1-11 and GAL2-11, can significantly inhibit the proliferation of OECs. But the influence can be blocked by M35, nonspecific antagonist of galanin receptors.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Bulbo Olfatório
/
Galanina
/
Receptores de Galanina
Limite:
Animals
Idioma:
Zh
Revista:
Shi Yan Sheng Wu Xue Bao
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China