Privileged structure based ligands for melanocortin receptors--substituted benzylic piperazine derivatives.
Bioorg Med Chem Lett
; 15(22): 4973-8, 2005 Nov 15.
Article
em En
| MEDLINE
| ID: mdl-16169215
ABSTRACT
Replacement of the aryl piperazine moiety in compound 1 with a variety of substituted benzylic piperazines (6) yields compounds that afford melanocortin receptor 4 (MCR4) activity. Analogs with ortho substitution on the aromatic ring afforded the highest affinity. Resolution of the stereocenter of the benzylic piperazine based privileged structure revealed that the R-enantiomer was more active.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Piperazinas
/
Derivados de Benzeno
/
Receptores de Melanocortina
Idioma:
En
Revista:
Bioorg Med Chem Lett
Assunto da revista:
BIOQUIMICA
/
QUIMICA
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
Estados Unidos