Impaired hippocampal long-term potentiation in melatonin MT2 receptor-deficient mice.
Neurosci Lett
; 393(1): 23-6, 2006 Jan 23.
Article
em En
| MEDLINE
| ID: mdl-16203090
ABSTRACT
The pineal product melatonin that acts on specific melatonin receptors has been implicated in pathobiological mechanisms of neuropsychiatric disorders including Alzheimer's disease. We used mice lacking melatonin MT(2) receptors (MT(2) knockouts) to investigate the role of these receptors in synaptic plasticity and learning-dependent behavior. In field CA1 of hippocampal slices from wild-type mice, theta burst stimulation induced robust and stable long-term potentiation that was smaller and decremental in slices from MT(2) knockouts. Tested in an elevated plus-maze on two consecutive days, wild-type mice showed shorter transfer latencies to enter a closed arm on the second day; this experience-dependent behavior did not occur in MT(2) knockouts. These results suggest that MT(2) receptors participate in hippocampal synaptic plasticity and in memory processes.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Potenciação de Longa Duração
/
Receptor MT2 de Melatonina
/
Hipocampo
Limite:
Animals
Idioma:
En
Revista:
Neurosci Lett
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Estados Unidos