[A randomized controlled and multicenter clinical study of ferrous L-threonate in treatment of iron deficiency anemia].
Zhonghua Nei Ke Za Zhi
; 44(11): 844-7, 2005 Nov.
Article
em Zh
| MEDLINE
| ID: mdl-16316567
ABSTRACT
OBJECTIVE:
To study the clinical efficacy and side effects of ferrous L-threonate for treatment of iron deficiency anemia (IDA).METHODS:
It is a multicentral, randomized, double blind, double placebo and paralled comparative study with positive control. One hundred and forty IDA patients diagnosed according to the standard criteria in three hospitals were randomly divided into a test group (ferrous L-threonate plus placebo ferrous succinate) and a positive control group (ferrous succinate plus placebo ferrous L-threonate). Some iron parameters were examined 1, 4 and 8 weeks after medication. Hemoglobin, reticulocyte and other parameters for safety observation were collected every two weeks.RESULTS:
For the 2 groups, self comparison showed significant difference (P < 0.01). The total efficacy is 98.44% and 97.01% respectively with no difference. Hemoglobin rised rapidly and gradually and reached a peak in week 8, the change was statistically significant (P < 0.01). Changes of iron parameters also showed significant difference. Side-effects were similar in both groups (13.85% and 14.71%, P > 0.05).CONCLUSION:
The effect of ferrous L-threonate in IDA treatment is significant and rapid. Side-effects are few and minimal.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Ferrosos
/
Anemia Ferropriva
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
Zh
Revista:
Zhonghua Nei Ke Za Zhi
Ano de publicação:
2005
Tipo de documento:
Article
País de afiliação:
China