Acute megakaryoblastic leukemia and loss of the RUNX1 gene.
Cancer Genet Cytogenet
; 164(1): 71-3, 2006 Jan 01.
Article
em En
| MEDLINE
| ID: mdl-16364766
ABSTRACT
Since the RUNX1 gene contributes to megakaryopoiesis and acquired trisomy 21 is the most frequent numerical chromosome anomaly in acute megakaryoblastic leukemia (AMLK), a systematic study of RUNX1 abnormalities was performed by fluorescence in situ hybridization in AMLK patients. Four abnormalities were detected among 15 patients. One copy of RUNX1 was completeley or partially lost in three patients and translocated onto Xq24 in the fourth. The possible consequences of RUNX1 haploinsufficiency are discussed.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Leucemia Megacarioblástica Aguda
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Deleção de Genes
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Subunidade alfa 2 de Fator de Ligação ao Core
Limite:
Adult
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Aged
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Child, preschool
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Female
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Humans
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Infant
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Male
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Middle aged
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Newborn
Idioma:
En
Revista:
Cancer Genet Cytogenet
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
França