The cytoskeleton of Entamoeba histolytica: structure, function, and regulation by signaling pathways.
Arch Med Res
; 37(2): 234-43, 2006 Feb.
Article
em En
| MEDLINE
| ID: mdl-16380324
ABSTRACT
Pathogenesis in the parasite Entamoeba histolytica has been related to motility of the trophozoites. Motility is an important feature in amebas as they perform multiple motile functions during invasion of host tissues. As motility depends on the organization and regulation of the cytoskeleton elements, in particular of the actin cytoskeleton, the study of the molecular components of the machinery responsible for movement has been a key aspect to study in this parasite. Although many of the components have high homology in amino acid sequence and function to those characterized in higher eukaryotic cells, there are important differences to suggest that parasitic organisms may have developed adaptative differences that could be useful as targets to stop invasion. The purpose of this review is to evaluate current knowledge about the cytoskeleton of E. histolytica and the ways in which the parasite controls motility.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
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Transdução de Sinais
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Entamoeba histolytica
Limite:
Animals
Idioma:
En
Revista:
Arch Med Res
Assunto da revista:
MEDICINA
Ano de publicação:
2006
Tipo de documento:
Article