[Antidepressives and antidepressive interactions with other drugs]. / Antidepresivi i interakcije antidepresiva s drugim lijekovima.

ABSTRACT

During the therapy with antidepressive agents, for the reason of its duration, numerous drug-drug interactions may occur. Antidepressive agents inhibit P450 enzyme activity and interfere with other drug metabolism. Many interactions are acceptable from the clinical point of view, and some are seriously dangerous indicating a need for their better knowledge. The aim of this work is to point out the possible interactions between antidepressive agents and other drugs.