Identification of deletion mutations and three new genes at the familial polyposis locus.
Cell
; 66(3): 601-13, 1991 Aug 09.
Article
em En
| MEDLINE
| ID: mdl-1678319
ABSTRACT
Small (100-260 kb), nested deletions were characterized in DNA from two unrelated patients with familial adenomatous polyposis coli (APC). Three candidate genes located within the deleted region were ascertained and a previous candidate gene, MCC, was shown to be located outside the deleted region. One of the new genes contained sequence identical to SRP19, the gene coding for the 19 kd component of the ribosomal signal recognition particle. The second, provisionally designated DP1 (deleted in polyposis 1), was found to be transcribed in the same orientation as MCC. Two other cDNAs, DP2 and DP3, were found to overlap, forming a single gene, DP2.5, that is transcribed in the same orientation as SRP19.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Polipose Adenomatosa do Colo
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
En
Revista:
Cell
Ano de publicação:
1991
Tipo de documento:
Article