Anorexia-Cachexia syndrome in cancer: implications of the ubiquitin-proteasome pathway.
Support Care Cancer
; 14(12): 1173-83, 2006 Dec.
Article
em En
| MEDLINE
| ID: mdl-16819628
ABSTRACT
INTRODUCTION:
Malnutrition is a common problem in cancer patients. Its incidence varies according to disease stage (between 15 and 90%) and is considered a possible prognostic factor for therapeutic response and survival. It is also one of the causes contributing to the increase in morbidity and mortality in patients. Tumor cachexia is defined as a nutritional defect caused by tumor growth in the patient and presents as a significant weight loss. This weight loss is mainly caused by a degradation of skeletal muscle proteins.CONCLUSION:
The ubiquitin-proteasome system is the most important pathway of protein degradation. As a regulatory system governing protein half-life, it is involved in the regulation of the cell cycle, signal transmission, immune system response, apoptosis, and oncogenesis. Knowledge of the molecular pathways involved in the induction of cancer-associated cachexia will favor a more rational approach to its treatment as well as possible quality of life and survival benefit for the patient.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Caquexia
/
Anorexia
/
Ubiquitina
/
Complexo de Endopeptidases do Proteassoma
/
Neoplasias
Tipo de estudo:
Prognostic_studies
Limite:
Humans
Idioma:
En
Revista:
Support Care Cancer
Assunto da revista:
NEOPLASIAS
/
SERVICOS DE SAUDE
Ano de publicação:
2006
Tipo de documento:
Article
País de afiliação:
Espanha