[Prevention of peritoneal adhesions to intraperitoneal prostheses. An experimental study in pigs]. / Prevención de adherencias peritoneales a las prótesis intraperitoneales. Estudio experimental en cerdos.
Cir Esp
; 80(4): 214-9, 2006 Oct.
Article
em Es
| MEDLINE
| ID: mdl-17040671
ABSTRACT
INTRODUCTION:
The aim of this study was to investigate the effect of fibrin glue and hyaluronidase gel on the prevention of postoperative peritoneal adhesions to intraperitoneal prostheses. MATERIAL ANDMETHOD:
Twenty pigs, divided in two groups, were included. In all animals, four implants (4 x 4 cm) were placed two polypropylene mesh implants were placed in an upper location and two polytetrafluoroethylene (PTFE) implants (Dualmesh Plus Corduroy) were placed in a lower position. Implants located in the right side of the animals were painted with fibrin glue (group A, n = 10) or with hyaluronidase gel (group B, n = 10). After 5 weeks, the animals were sacrificed and the results (number and grade of intraperitoneal adhesions, histological data on prosthesis integration, such as mesothelialization, fibroblast infiltration, vessel neoformation, etc.) were evaluated.RESULTS:
Intraperitoneal adhesions decreased in implants painted with fibrin glue and hyaluronidase gel compared with untreated implants. When right-sided adhesions formed, they were looser and in many animals, the implants were completely peritonized. Integration of the prostheses was not affected by either fibrin glue or hyaluronidase gel.CONCLUSIONS:
Adhesion formation can be reduced after abdominal surgery. The reduction achieved in this study was greater in the quantity than in the consistency of the adhesions. The results with hyaluronidase gel were moderately superior to those obtained with fibrin glue. Hyaluronidase gel has the advantage of being inexpensive.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Doenças Peritoneais
/
Próteses e Implantes
/
Aderências Teciduais
Tipo de estudo:
Etiology_studies
/
Prognostic_studies
Limite:
Animals
Idioma:
Es
Revista:
Cir Esp
Ano de publicação:
2006
Tipo de documento:
Article