Double cortex. A neuronal migration anomaly as a possible cause of Lennox-Gastaut syndrome.
Arch Neurol
; 49(1): 61-4, 1992 Jan.
Article
em En
| MEDLINE
| ID: mdl-1728265
ABSTRACT
Band heterotopia, or "double cortex," is a neuronal migration disorder that consists of a symmetrical subcortical neuronal band. The overlying cortex may be normal or macrogyric. We describe two severely mentally retarded girls, aged 14 and 18 years, who had band heterotopia and Lennox-Gastaut syndrome. Band heterotopia was evident in both hemispheres as a subcortical symmetrical layer isointense with gray matter on magnetic resonance T1- and T2-weighted images. Both patients had atonic seizures, atypical absences, and tonic seizures. The electroencephalograms in both cases showed frequent generalized paroxysms and slow background activity. The association of a Lennox-Gastaut syndrome with double cortex in these two patients and in a previously reported autopsy-confirmed case suggests that this malformation may be responsible for other similar cases.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Convulsões
/
Córtex Cerebral
/
Epilepsia
/
Hemiplegia
Tipo de estudo:
Etiology_studies
Limite:
Adolescent
/
Female
/
Humans
Idioma:
En
Revista:
Arch Neurol
Ano de publicação:
1992
Tipo de documento:
Article
País de afiliação:
Itália