Does modafinil enhance activity of patients with myotonic dystrophy?: a double-blind placebo-controlled crossover study.
J Neurol
; 254(1): 26-8, 2007 Jan.
Article
em En
| MEDLINE
| ID: mdl-17285226
ABSTRACT
We performed a double-blind placebo-controlled crossover study in 13 patients with myotonic dystrophy to address the question whether modafinil, known to improve hypersomnolence in myotonic dystrophy, may improve levels of activity as well. We used the Epworth Sleepiness Scale as a measure of hypersomnolence and a structured interview of the patient and the partner or housemate as a measure of activity. We additionally used a restricted form of the RAND-36 to relate a possible improvement of activity to perceived general health. We confirmed earlier positive findings of modafinil regarding reduced somnolence (p=0.015), but no significant effects were seen regarding activity levels (p=0.2 for patients' self-reports and 0.5 for partners' reports).
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Compostos Benzidrílicos
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Atividades Cotidianas
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Fármacos Neuroprotetores
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Atividade Motora
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Distrofia Miotônica
Tipo de estudo:
Clinical_trials
/
Qualitative_research
Limite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
J Neurol
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Holanda