[Optimization of preparative technique for banxia-houpu effervescent tablets by orthogonal design].

ABSTRACT

OBJECTIVE: To optimize preparative technique for banxia-houpu effervescent tablets. METHODS: Based on the pH, disintegration time limited, taste, and rigidity of effervescent tablets, the proper proportion between citric acid and sodium bicarbonate, as well as the proper quantity of polyethylene glycol 6000 and sodium cyclamate in the effervescent tablets were determined by using orthogonal design. The content of magnolol and honokiol in effervescent tablets were measured by HPLC. RESULTS: The optimal preparative technique was cirtic acid sodium bicarbonate = 0.651. The percentage of polyethylene glycol 6000 was 85%, and the percentage of sodium cyclamate was 1.0%. CONCLUSION: The preparative technique is stable, reliable and suitable for practical use.