Combining hierarchical and associative gene ontology relations with textual evidence in estimating gene and gene product similarity.
IEEE Trans Nanobioscience
; 6(1): 51-9, 2007 Mar.
Article
em En
| MEDLINE
| ID: mdl-17393850
ABSTRACT
Two approaches have recently emerged where the similarity between two genes or gene products is obtained by comparing Gene Ontology (GO) annotations associated with the genes or gene products. One approach captures GO-based similarity in terms of hierarchical relations within each gene subontology, while the other relies on associative relations across the three gene subontologies. We propose a novel methodology where the two approaches can be merged and enriched by textual evidence extracted from biomedical literature with ensuing benefits in coverage and stronger correlation with sequence-based similarity.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Publicações
/
Processamento de Linguagem Natural
/
Reconhecimento Automatizado de Padrão
/
Proteínas
/
Armazenamento e Recuperação da Informação
/
Genes
Tipo de estudo:
Evaluation_studies
/
Risk_factors_studies
Idioma:
En
Revista:
IEEE Trans Nanobioscience
Assunto da revista:
BIOTECNOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Estados Unidos