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Influence of the substrate's hydrophilicity on the in vitro Schwann cells viability.
Soria, J M; Martínez Ramos, C; Bahamonde, O; García Cruz, D M; Salmerón Sánchez, M; García Esparza, M A; Casas, C; Guzmán, M; Navarro, X; Gómez Ribelles, J L; García Verdugo, J M; Monleón Pradas, M; Barcia, J A.
Afiliação
  • Soria JM; Fundación Hospital General Universitario de Valencia, Avda. Tres Cruces s/n, 46014 Valencia, Spain. soria_jos@gva.es
J Biomed Mater Res A ; 83(2): 463-70, 2007 Nov.
Article em En | MEDLINE | ID: mdl-17477391
A series of polymeric biomaterials including poly (methyl acrylate) (PMA), chitosan (CHT), poly(ethyl acrylate) (PEA), poly(hydroxyethyl acrylate) (PHEA), and a series of random copolymers containing ethyl acrylate and hydroxyethyl acrylate monomeric units were tested in vitro as culture substrates and compared for their impact on the proliferation and expansion of Schwann cells (SCs). Immunocytochemical staining assay and scanning electron microscopy techniques were applied to perform a quantitative analysis to determine the correct maintenance of the cultured glial cells on the different biomaterials. The results strongly suggest that cell attachment and proliferation is influenced by the substrate's surface chemistry, and that hydrophobic biomaterials based on PMA, PEA, and the copolymers PEA and PHEA in a narrow composition window are suitable substrates to promote cell attachment and proliferation of SCs in vitro.
Assuntos
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Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células de Schwann Limite: Animals Idioma: En Revista: J Biomed Mater Res A Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Espanha
Buscar no Google
Coleções: 01-internacional Base de dados: MEDLINE Assunto principal: Células de Schwann Limite: Animals Idioma: En Revista: J Biomed Mater Res A Assunto da revista: ENGENHARIA BIOMEDICA Ano de publicação: 2007 Tipo de documento: Article País de afiliação: Espanha