Cloning of cDNA encoding rat TCP-1.
Biochim Biophys Acta
; 1129(1): 96-9, 1991 Dec 02.
Article
em En
| MEDLINE
| ID: mdl-1756183
ABSTRACT
We have isolated and sequenced a cDNA encoding a rat homolog of the mouse t-complex polypeptide 1 (TCP-1). Its deduced gene product is a polypeptide of 556 amino acids, with a predicted Mr of 60,341. The similarity between mouse Tcp-1 and the rat homolog is about 94.0% at the nucleotide level and 97.1% at the amino acid level showing the evolutionary conservation of this protein. The similarity of the amino acid sequence of the rat TCP-1 is not significantly biased to any of those from wild (TCP-1B) or from t-haplotype mice (TCP-1A). From a comparison of deduced amino acid sequences of eukaryotic TCP-1 proteins, we found highly conserved domains. Southern blot analysis revealed that there are at least two similar sequences to Tcp-1 in the rat, one is a structural gene and the other seems to be a processed pseudogene.
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01-internacional
Base de dados:
MEDLINE
Assunto principal:
Ratos
/
Proteínas Nucleares
/
Peptídeos e Proteínas de Sinalização Intracelular
/
Proteínas Associadas aos Microtúbulos
Limite:
Animals
Idioma:
En
Revista:
Biochim Biophys Acta
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
Japão