Curcumin affects development of zebrafish embryo.
Biol Pharm Bull
; 30(7): 1336-9, 2007 Jul.
Article
em En
| MEDLINE
| ID: mdl-17603177
ABSTRACT
Embryotoxic and teratogenic effects of curcumin on the development of zebrafish embryo were investi-gated in this study. The LD(50) values of curcumin (24-h incubation) were estimated at 7.5 microM and 5 microM for embryos and larvae, respectively. The developmental defects caused by curcumin treatments include bent or hook-like tails, spinal column curving, edema in pericardial sac, retarded yolk sac resorption, and shorter body length. In curcumin-treated larvae, fluorescence signals of curcumin were found in edamae sac and some skin cells. Together, these results indicate that zebrafish are suitable model organisms to study the toxic effects of curcumin.
Buscar no Google
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Anormalidades Induzidas por Medicamentos
/
Peixe-Zebra
/
Curcumina
/
Embrião não Mamífero
Limite:
Animals
Idioma:
En
Revista:
Biol Pharm Bull
Assunto da revista:
BIOQUIMICA
/
FARMACOLOGIA
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
China