Pasteurella multocida septic shock following liver transplantation treated with drotrecogin alpha (activated).
Transpl Infect Dis
; 9(3): 233-6, 2007 Sep.
Article
em En
| MEDLINE
| ID: mdl-17692071
ABSTRACT
Severe sepsis and progression to septic shock in solid organ transplant recipients is associated with a high mortality. We describe a fulminant case of septic shock in a liver transplant recipient caused by Pasteurella multocida, a gram-negative coccobacillus most commonly associated with domestic cats and dogs. P. multocida is a rare cause of bacteremia and has not been reported as a cause of septic shock following liver transplantation. In addition to standard therapy, the patient was managed with drotrecogin alpha (activated) recombinant activated protein C (APC), an evidence-based agent that has been shown to significantly improve outcome in severe sepsis in the non-transplant population. The known risk factors, clinical course, and outcomes of severe infection associated with P. multocida are also briefly reviewed. This case illustrates the need for transplant recipients and their healthcare providers to carefully consider the risk of severe infection associated with domestic animal exposure.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Infecções por Pasteurella
/
Choque Séptico
/
Proteína C
/
Transplante de Fígado
/
Pasteurella multocida
Tipo de estudo:
Risk_factors_studies
Limite:
Animals
/
Humans
/
Male
/
Middle aged
Idioma:
En
Revista:
Transpl Infect Dis
Assunto da revista:
TRANSPLANTE
Ano de publicação:
2007
Tipo de documento:
Article
País de afiliação:
Canadá