Triple helix structures: sequence dependence, flexibility and mismatch effects.
J Biomol Struct Dyn
; 9(3): 411-24, 1991 Dec.
Article
em En
| MEDLINE
| ID: mdl-1815635
ABSTRACT
By means of molecular modelling, electrostatic interactions are shown to play an important role in the sequence-dependent structure of triple helices formed by a homopyrimidine oligonucleotide bound to a homopurine. homopyrimidine sequence on DNA. This is caused by the presence of positive charges due to the protonation of cytosines in the Hoogsteen-bonded strand, required in order to form C.GxC+ triplets. Energetic and conformational characteristics of triple helices with different sequences are analyzed and discussed. The effects of duplex mismatches on the triple helix stability are investigated via thermal dissociation using UV absorption.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
DNA
Tipo de estudo:
Prognostic_studies
Idioma:
En
Revista:
J Biomol Struct Dyn
Ano de publicação:
1991
Tipo de documento:
Article
País de afiliação:
França