The effect of lead on calcium release activated calcium influx in primary cultures of human osteoblast-like cells.
Arch Pharm Res
; 31(2): 188-94, 2008 Feb.
Article
em En
| MEDLINE
| ID: mdl-18365689
ABSTRACT
To further understand the significance of bone as a target tissues of lead toxicity, as well as a reservoir of systemic lead, it is necessary to define the effect of lead on the calcium release activated calcium influx (CRACI) in primary cultures of human osteoblast-like cells (OLC). Pb2+ inhibited the immediate CRACI dose-dependent manner. Influx of Pb2+ into human OLC was increased dose-dependent manner. The present study demonstrates that the interference of Pb2+ with CRACI of human OLC is at least twofold (1) the initiation of CRACI, i.e., the measurable influx of Ca2+ upon Ca2+ readdition, is partially inhibited by Pb2+ and (2) the influx of Pb2+ was enhanced after CRACI had been induced.
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Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Osteoblastos
/
Cálcio
/
Chumbo
Limite:
Humans
Idioma:
En
Revista:
Arch Pharm Res
Ano de publicação:
2008
Tipo de documento:
Article