Pre-mRNA splicing: a complex picture in higher definition.
Trends Biochem Sci
; 33(6): 243-6, 2008 Jun.
Article
em En
| MEDLINE
| ID: mdl-18472266
ABSTRACT
Intron excision from pre-mRNAs of higher eukaryotes requires a transition from splice-site recognition across short exons to organization of the spliceosome across long introns. Recently, insight into this transition has been provided and, in addition, it has been shown that an alternative splicing factor, the polypyrimidine-tract-binding protein, can exert its control on splice-site choice by blocking this key step in the assembly of the splicing machinery.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Precursores de RNA
/
Splicing de RNA
/
Spliceossomos
/
Sítios de Splice de RNA
/
Proteína de Ligação a Regiões Ricas em Polipirimidinas
/
Células Eucarióticas
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Trends Biochem Sci
Ano de publicação:
2008
Tipo de documento:
Article
País de afiliação:
Canadá