Magnetic resonance imaging abnormalities associated with vigabatrin in patients with epilepsy.
Epilepsia
; 50(2): 195-205, 2009 Feb.
Article
em En
| MEDLINE
| ID: mdl-19054414
ABSTRACT
PURPOSE:
Vigabatrin used to treat infantile spasms (IS) has been associated with transient magnetic resonance imaging (MRI) abnormalities. We carried out a retrospective review to better characterize the frequency of those abnormalities in IS and in children and adults treated with vigabatrin for refractory complex partial seizures (CPS).METHODS:
Medical records and 332 cranial MRIs from 205 infants (agedRESULTS:
Among infants with IS, the prevalence of prespecified MRI abnormalities was significantly higher among vigabatrin-treated versus vigabatrin-naive subjects (22% vs. 4%; p < 0.001). Of nine subjects in the prevalence population with at least one subsequent determinate MRI, resolution of MRI abnormalities occurred in six (66.7%)-vigabatrin was discontinued in four. Among adults and children treated with vigabatrin for CPS, there was no statistically significant difference in the incidence or prevalence of prespecified MRI abnormalities between vigabatrin-exposed and vigabatrin-naive subjects.DISCUSSION:
Vigabatrin is associated with transient, asymptomatic MRI abnormalities in infants treated for IS. The majority of these MRI abnormalities resolved, even in subjects who remained on vigabatrin therapy.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Espasmos Infantis
/
Processamento de Imagem Assistida por Computador
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Encéfalo
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Imageamento por Ressonância Magnética
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Epilepsia Parcial Complexa
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Vigabatrina
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Imagem de Difusão por Ressonância Magnética
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Anticonvulsivantes
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Limite:
Adolescent
/
Adult
/
Child
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Child, preschool
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Female
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Humans
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Infant
/
Male
Idioma:
En
Revista:
Epilepsia
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
Estados Unidos