The consequences of asynapsis for mammalian meiosis.
Nat Rev Genet
; 10(3): 207-16, 2009 Mar.
Article
em En
| MEDLINE
| ID: mdl-19188923
ABSTRACT
During mammalian meiosis, synapsis of paternal and maternal chromosomes and the generation of DNA breaks are needed to allow reshuffling of parental genes. In mammals errors in synapsis are associated with a male-biased meiotic impairment, which has been attributed to a response to persisting DNA double-stranded breaks in the asynapsed chromosome segments. Recently it was discovered that the chromatin of asynapsed chromosome segments is transcriptionally silenced, providing new insights into the connection between asynapsis and meiotic impairment.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Cromossomos
/
Pareamento Cromossômico
/
Meiose
Limite:
Animals
/
Female
/
Humans
/
Male
Idioma:
En
Revista:
Nat Rev Genet
Assunto da revista:
GENETICA
Ano de publicação:
2009
Tipo de documento:
Article