Effect of pro-inflammatory cytokine stimulation on human breast cancer: implications of chemokine receptor expression in cancer metastasis.
Cancer Lett
; 283(2): 176-85, 2009 Oct 08.
Article
em En
| MEDLINE
| ID: mdl-19409696
ABSTRACT
Interactions between tumour cells and microenvironments may affect their growth and metastasis formation. In search for a better understanding of the role of cellular mediators in the progression of cancer, we investigated the effect of pro-inflammatory cytokines IL-1, IL-6, TNF-alpha and IFN-gamma on the regulation of expression of chemokine receptors CXCR4, CXCR2, CX3CR1, CCR9, and CCR5 in the human breast cancer cell line MCF-7. Our results showed that IL-1 increased CXCR4 expression whereas TNF-alpha increased CX3CR1, CCR9 and CCR5. Interestingly, this regulation was not homogeneous, emphasizing the inherent heterogeneity in cancer that may be responsive to specific inflammatory microenvironments.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Mama
/
Citocinas
/
Receptores de Quimiocinas
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Metástase Neoplásica
Limite:
Female
/
Humans
Idioma:
En
Revista:
Cancer Lett
Ano de publicação:
2009
Tipo de documento:
Article
País de afiliação:
México